The aim of the present investigation is to develop a time and pH-dependent system for colon specific drug delivery of Tizanidine Hydrochloride. The colon specific drug delivery system (CDDS) is designed such that the innermost part consists of a core tablet of Tizanidine Hydrochloride which is then compressed with hydrophobic polymer (Sodium starch glycolate and microcrystalline cellulose). This is then coated with a pH-dependent methacrylic acid copolymer (Eudragit�® S100 and Eudragit�® L100). The concentration (coating level) of Eudragit�® S100 and Eudragit�® L100 was optimized to provide an enteric coat that allows the tablet to pass intact through the stomach and is targeted to the colon. The coating thicknesses were optimized to set a desired lag time in the intestine. From the in vitro evaluation it can revealed that the developed CDDS can exhibit site-specific drug targeting to the colon.
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